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Title   Glutathione S-Transferase 효소유전자 다형성과 자궁경부암의 유전적 감수성 ( Glutathione S-Transferase Polymorphisms and Genetic Susceptibility to Cernical Cancer )
Publicationinfo   1997 Jan; 029(04): 673-681.
Key_word   Cervical cancer, Genetic susceptibility, Glutathione S-Transferase
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Abstract   Purpose: The identification of genetic traits that predispose individuals to environmentally induced cancers is one of the challanges in the assessment of individual cancer risk The genetically determined differences in metabolism, related to glutathione S-transferases(GSTs) have been reported to be associated with various cancer susceptibility. The present study was set up to establish the frequencies of the polymorphic genotypes of two GST(GST- mu and GST-theta) isozymes in Korea, to evaluate a possible increased incidence of the genotypes associated with higher cervical cancer risks among Korean cervical cancer patients. Materials and Methods: In this study, extracted DNAs from cervical cancer patients(228 for GST-mu and 241 for GST-theta genotypes) and normal controls(360 for GST-mu and 353 for GST-theta genotypes) were analysed with the polymerase chain reaction(PCR). Results: The overall genotype distribution of the GST-theta polymorphisms was not statistically different between the patients and control groups. But, in the GST-mu null geno- types, there were remarkable differences between patients and control groups when the cervical cancer patients were devided into subgroups with respect to the age. The frequency of GST-mu null polymorphisms in the cervical cancer patients under the 40 years old was significantly higher compared to the patients above the 40 years old(0.01 < P < 0.05). In cervical carcinoma, the polymorphic genotypes of GST-mu null were correlated to far advanced clinical stages(stages III and IV)(0.05
저 자   김진우(Jin Woo Kim),이춘근(Choon Geun Lee),손여원(Ye Won Son),민홍기(Hong Ki Min),한수미(Soo Mi Han),조은영(Eun Young Cho),김경숙(Kyung Sook Kim),신진웅(Jin Woong Shin),김사진(Sa Jin Kim),박태철(Tae Cheol Park),이준모(Joon Mo Lee),남궁성은(Sung Eun NamGoong)